Positive regulation of focal adhesion assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of focal adhesion assembly pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKG1, TLN2, and YME1L1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of focal adhesion assembly activity versus PRKG1 in UCEC (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRKG1 →	+0.800	+0.088	<.001	<.001	3	9
BRCA	TLN2 →	+0.700	+0.069	<.001	<.001	3	9
LSCC	YME1L1 →	-0.393	-0.102	<.001	<.001	3	9
BRCA	COL6A2 →	+0.670	+0.054	<.001	<.001	3	9
OV	LAMB1 →	+0.583	+0.078	<.001	<.001	3	9
OV	NID2 →	+0.559	+0.076	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051894 vs PRKG1 — UCEC

Explore this scatter interactively →