Positive regulation of focal adhesion assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of focal adhesion assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHE, MAGI2-AS3, and PDE1A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of focal adhesion assembly activity versus SHE in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SHE →	+0.436	+0.156	<.001	<.001	3	8
BRCA	MAGI2-AS3 →	+0.546	+0.121	<.001	.003	3	7
LSCC	PDE1A →	+0.676	+0.467	<.001	.008	3	6
LSCC	TIMP3 →	+0.675	+0.436	.004	.003	3	6
COAD	ACTA2 →	+0.930	+0.216	<.001	.006	3	6
CCRCC	LDB2 →	+0.759	+0.431	.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051894 vs SHE — BRCA

Explore this scatter interactively →