Positive regulation of focal adhesion assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of focal adhesion assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLTC, BRD4, and MAP3K8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLTC grouped by Positive regulation of focal adhesion assembly-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CLTC →	-0.479	-0.086	<.001	.001	3	6
BREAST	BRD4 →	-0.290	-0.168	<.001	<.001	3	6
LUNG_SCLC	MAP3K8 →	-0.211	-0.211	<.001	.002	3	5
LUNG_SCLC	EIF4G1 →	-0.394	-0.201	.002	.003	3	5
BONE	MAX →	-0.559	-0.334	.004	<.001	2	6
LUNG_SCLC	FOXS1 →	+0.267	+0.222	.005	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLTC by Positive regulation of focal adhesion assembly activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →