Positive regulation of focal adhesion assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of focal adhesion assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD200R1, TBCE, and POLD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD200R1 grouped by Positive regulation of focal adhesion assembly-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CD200R1 →	+0.180	+0.384	.005	<.001	3	4
BREAST	TBCE →	+0.363	+0.202	.006	.002	2	5
BLOOD_Leukemia	POLD2 →	+0.351	+0.274	.003	.001	3	3
STOMACH	ATF1 →	+0.238	+0.238	.003	.007	3	3
STOMACH	IGFBP4 →	+0.227	+0.340	.006	<.001	3	3
STOMACH	GDNF →	-0.495	-0.385	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD200R1 by Positive regulation of focal adhesion assembly activity — STOMACH

Explore this box plot interactively →