Pigment granule localization

Across TCGA patient cohorts, RNA activity of the Pigment granule localization pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIAA1109, TIGD4, and RBL2, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pigment granule localization activity versus KIAA1109 in THYM (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	KIAA1109 →	+1.164	+0.036	<.001	<.001	3	31
ACC	TIGD4 →	+0.720	+0.052	<.001	<.001	3	30
ACC	RBL2 →	+1.432	+0.044	<.001	<.001	3	30
ACC	DNAJB14 →	+1.171	+0.054	<.001	<.001	3	30
THYM	TMEM184C →	+0.926	+0.036	<.001	<.001	3	30
ACC	RBM41 →	+0.889	+0.050	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051875 vs KIAA1109 — THYM

Explore this scatter interactively →