Pigment granule localization

Across TCGA patient cohorts, RNA activity of the Pigment granule localization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MLPH, AIM2, and MYO5C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pigment granule localization activity versus MLPH in BRCA (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MLPH →	+1.838	+0.474	<.001	<.001	3	5
PDAC	AIM2 →	-0.728	-0.783	.006	<.001	3	5
BRCA	MYO5C →	+0.659	+0.514	<.001	<.001	3	5
BRCA	BCAS1 →	+2.155	+0.715	<.001	<.001	3	5
BRCA	CENPW →	-1.210	-0.578	<.001	.005	3	5
UCEC	CXCL10 →	-1.044	-0.362	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051875 vs MLPH — BRCA

Explore this scatter interactively →