Pigment granule localization

Across TCGA cell cohorts, RNA activity of the Pigment granule localization pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF567, H1-4, and HSD17B11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF567 grouped by Pigment granule localization-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZNF567 →	+0.193	+1.642	<.001	.002	3	4
BLOOD_Myeloma	H1-4 →	+0.310	+1.980	.008	<.001	2	5
BLOOD_Lymphoma	HSD17B11 →	-0.466	-2.346	.006	<.001	3	4
BLOOD_Lymphoma	PKD1 →	-0.242	-1.708	.002	.004	3	4
CNS	GSTM2P1 →	+0.318	+1.526	.004	<.001	3	4
KIDNEY	OCSTAMP →	+0.200	+1.294	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF567 by Pigment granule localization activity — SOFT_TISSUE

Explore this box plot interactively →