Pigment granule localization

Across TCGA cell cohorts, RNA activity of the Pigment granule localization pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNRPA, TAF15, and RAB32, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pigment granule localization activity versus SNRPA in LIVER (Pearson r = -0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SNRPA →	-0.968	-1.456	.005	<.001	3	8
OESOPHAGUS	TAF15 →	-0.850	-1.209	.008	<.001	2	9
BLOOD_Leukemia	RAB32 →	+2.220	+0.695	.003	.003	2	7
LUNG_SCLC	H1-10 →	-1.131	-1.046	.003	<.001	3	6
BLOOD_Leukemia	BCAS4 →	-2.015	-0.693	.005	.008	3	6
BLOOD_Leukemia	SLC22A4 →	+1.911	+0.933	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051875 vs SNRPA — LIVER

Explore this scatter interactively →