Medium-chain fatty acid catabolic process

Across TCGA cell cohorts, RNA activity of the Medium-chain fatty acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC35D1, SCN1B, and JAK3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC35D1 grouped by Medium-chain fatty acid catabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SLC35D1 →	+0.608	+1.048	.002	.004	3	4
STOMACH	SCN1B →	+1.891	+1.775	.008	<.001	3	4
LUNG_NSCLC_LUSC	JAK3 →	-0.765	-1.110	<.001	.006	3	3
LUNG_NSCLC_LUSC	CCN1 →	-3.765	-1.473	.003	.003	3	3
LUNG_NSCLC_LUSC	HLA-B →	-3.056	-1.692	.001	.001	3	3
KIDNEY	PTPRB →	-1.451	-1.169	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC35D1 by Medium-chain fatty acid catabolic process activity — OVARY

Explore this box plot interactively →