Medium-chain fatty acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Medium-chain fatty acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPC6, LINC02056, and ENTPD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Medium-chain fatty acid biosynthetic process activity versus GPC6 in LSCC (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GPC6 →	-0.547	-0.110	.003	.003	3	4
COAD	LINC02056 →	-0.068	-0.132	.009	.002	3	3
PDAC	ENTPD2 →	+0.496	+0.177	.008	.006	3	3
LSCC	CNN1 →	-0.501	-0.127	.003	<.001	3	3
LSCC	SYNE1 →	-0.604	-0.138	.001	.002	3	3
LSCC	ARMCX2 →	-0.907	-0.158	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051792 vs GPC6 — LSCC

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