Response to misfolded protein

Across TCGA patient cohorts, RNA activity of the Response to misfolded protein pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS2, RPL11, and SORBS1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to misfolded protein activity versus RPS2 in LUAD (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPS2 →	-0.207	-0.042	<.001	<.001	3	8
PDAC	RPL11 →	-0.243	-0.037	<.001	<.001	3	7
LSCC	SORBS1 →	+0.274	+0.041	.002	<.001	3	7
HNSC	RPL10A →	-0.175	-0.075	.002	.002	3	7
LUAD	RPL7L1 →	-0.431	-0.040	<.001	<.001	3	6
BRCA	CNRIP1 →	+0.463	+0.027	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051788 vs RPS2 — LUAD

Explore this scatter interactively →