GO:0051788Ontology (GO BP)GO biological process · ~25 member genes
Q-omics provides the Response to misfolded protein (GO:0051788) pathway profile, scoring each patient from the combined activity of its roughly 25 member genes. Pathway activity is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, the pathway is differentially active in 11, with the highest sampling consensus in COAD. Additionally, pathway RNA activity shows 36,785 significant cross-omics associations, again with the highest sampling consensus in HNSC. Together, these results highlight UVM, COAD, and HNSC as cancer lineages where the pathway shows reproducible signals across outcome, tissue activity, and molecular association analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns. Pathway-against-pathway and pathway-against-mutation comparisons are not available for ontology entities.
Survival associations
This table summarizes Response to misfolded protein survival associations by molecular data type. RNA-level pathway activity shows survival associations in the most cancer types (27). The rightmost column indicates the cancer type with the highest sampling consensus for each layer.
This table ranks reproducible pathway activity–survival associations across cancer types. High Response to misfolded protein activity shows favorable associations in MESO, SKCM and HNSC, but unfavorable associations in UVM, ACC and UCEC. In the UVM Kaplan–Meier curve the high-activity group declines faster, consistent with the unfavorable association (log-rank p = .002). UVM ranks highest by sampling consensus for Response to misfolded protein.
This table summarizes Response to misfolded protein tumor–normal activity differences by data type. RNA-level activity shows significant tumor–normal differences in 11 cancer types, while mass-spec protein activity shows differences in 4. The strongest signals are in COAD for RNA and LUAD for protein.
This table ranks reproducible tumor–normal activity differences for the pathway. A positive fold-change indicates higher activity in tumor tissue. The pathway shows higher tumor activity across COAD and lower tumor activity in THCA, KIRC, BRCA, KICH and UCEC. In the COAD box plot, tumor samples show higher pathway activity than matched normal samples (log2 FC = +0.041, t-test p < 0.001).
This table shows molecular features associated with Response to misfolded protein pathway activity in patient tissues and cancer cell lines. In patient samples, pathway activity is most strongly linked to RNA and protein features, with the largest associated set in HNSC. In cancer cell lines, RNA-expression features and functional dependencies dominate, with the largest set in SKIN.
