Negative regulation of nuclear division

Across TCGA cell cohorts, RNA activity of the Negative regulation of nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF114, EMC1, and SNX22, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of nuclear division activity versus RNF114 in CNS (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RNF114 →	-0.602	-0.862	.005	.005	3	3
BLOOD_Leukemia	EMC1 →	-0.522	-0.404	.004	.007	3	3
OVARY	SNX22 →	+0.537	+0.713	.001	.001	3	3
KIDNEY	SHROOM3 →	+1.647	+1.137	.004	.001	3	3
LIVER	SLC4A1AP →	-0.524	-1.169	.008	.001	3	3
LIVER	NBPF26 →	-1.160	-0.891	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051784 vs RNF114 — CNS

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