Regulation of nuclear division

Across TCGA cell cohorts, RNA activity of the Regulation of nuclear division pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are A4GALT, DPP7, and GPA33, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, A4GALT grouped by Regulation of nuclear division-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	A4GALT →	+0.249	+0.178	.006	.005	3	6
LUNG_NSCLC_LUAD	DPP7 →	+0.134	+0.105	.002	.003	3	6
LUNG_NSCLC_LUSC	GPA33 →	+0.244	+0.157	.001	.007	3	5
BLOOD_Lymphoma	SETD1A →	-0.473	-0.470	.009	.003	3	5
URINARY_TRACT	WDR86 →	+0.254	+0.178	.005	.006	3	5
CNS	OR10K2 →	+0.281	+0.202	.001	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

A4GALT by Regulation of nuclear division activity — KIDNEY

Explore this box plot interactively →