Regulation of nuclear division

Across TCGA cell cohorts, RNA activity of the Regulation of nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB38, TMEM104, and KIFBP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB38 grouped by Regulation of nuclear division-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RAB38 →	+1.727	+0.137	.001	.005	3	5
OESOPHAGUS	TMEM104 →	+0.598	+0.139	.005	.007	3	4
PANCREAS	KIFBP →	-0.682	-0.144	.002	.006	3	4
LUNG_SCLC	MZF1 →	+1.207	+0.169	<.001	.002	3	4
BLOOD_Leukemia	COL7A1 →	+1.098	+0.177	.005	.003	3	4
STOMACH	TSEN15 →	-0.822	-0.165	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB38 by Regulation of nuclear division activity — OVARY

Explore this box plot interactively →