Positive regulation of cell division

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell division pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNT5B, BMT2, and CCDC18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell division activity versus WNT5B in BRCA (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	WNT5B →	+0.588	+0.737	.008	.002	3	5
OV	BMT2 →	+0.396	+0.617	.003	.006	3	4
UCEC	CCDC18 →	+0.373	+0.499	.006	.003	3	4
UCEC	MTFR2 →	+0.712	+0.834	.002	<.001	3	4
UCEC	HTRA4 →	-0.780	-0.790	.008	.001	3	4
LUAD	EIF5B →	+0.262	+0.601	.007	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051781 vs WNT5B — BRCA

Explore this scatter interactively →