Positive regulation of cell division

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of cell division pathway is associated with patient survival in 29 of 34 cancer lineages. Pathway activity is summarized from the expression of its 94 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Positive regulation of cell division pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as DLBC and UCS, show the opposite pattern, with higher activity associated with better survival.

KIRP, MESO, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.580	0.760	<.001	146	view →
MESO	OS	Median	All	0.416	0.644	<.001	114	view →
ACC	OS	Median	All	0.423	0.766	<.001	110	view →
LIHC	DFS	Median	All	0.447	0.615	<.001	90	view →
PAAD	DFS	Quartile	All	0.148	0.436	<.001	57	view →
KIRC	DFS	Median	All	0.557	0.706	.001	54	view →
LGG	DFS	Median	All	0.618	0.820	<.001	54	view →
UVM	DFS	Quartile	III,IV	0.288	0.931	<.001	31	view →
CESC	DFS	Tertile	All	0.697	0.889	<.001	30	view →
SARC	OS	Median	All	0.388	0.610	<.001	26	view →
LUAD	OS	Median	All	0.762	0.843	.006	26	view →
UCEC	DFS	Tertile	All	0.550	0.695	<.001	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

GO:0051781–KIRP (OS)

Open the KIRP breakdown →