Positive regulation of cell division

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell division pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEK2, C17orf67, and UBE2O, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLEK2 grouped by Positive regulation of cell division-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PLEK2 →	+2.237	+0.107	.003	.007	3	4
LUNG_SCLC	C17orf67 →	+0.576	+0.132	.003	.003	3	4
SKIN	UBE2O →	-0.724	-0.191	<.001	.001	3	4
SKIN	LASP1 →	+0.871	+0.234	.001	.003	3	4
SKIN	COL17A1 →	+0.568	+0.225	.008	<.001	3	4
PANCREAS	MPZ →	+0.750	+0.255	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLEK2 by Positive regulation of cell division activity — LUNG_SCLC

Explore this box plot interactively →