Positive regulation of cell division

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell division pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VMP1, RNASET2, and USP42, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell division activity versus VMP1 in BONE (Pearson r = -0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	VMP1 →	-1.512	-0.225	.008	.007	3	4
LUNG_NSCLC_LUAD	RNASET2 →	-1.220	-0.144	<.001	.001	3	4
BLOOD_Leukemia	USP42 →	+0.801	+0.155	<.001	.001	3	4
BLOOD_Leukemia	C11orf95 →	+0.775	+0.143	.004	.003	3	4
BLOOD_Leukemia	PROB1 →	+1.110	+0.207	.002	<.001	3	4
BLOOD_Leukemia	SGPP1 →	+1.692	+0.165	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051781 vs VMP1 — BONE

Explore this scatter interactively →