Actin crosslink formation

Across TCGA patient cohorts, RNA activity of the Actin crosslink formation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SULF1, BAIAP2L1, and UPP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin crosslink formation activity versus SULF1 in CCRCC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SULF1 →	+0.737	+0.053	.004	.001	3	6
PDAC	BAIAP2L1 →	+0.650	+0.049	<.001	<.001	3	6
GBM	UPP1 →	+0.832	+0.055	<.001	<.001	3	6
CCRCC	FN1 →	+0.850	+0.076	<.001	<.001	3	6
CCRCC	PLS3 →	+0.338	+0.057	<.001	<.001	3	6
GBM	FLNA →	+0.333	+0.042	.004	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051764 vs SULF1 — CCRCC

Explore this scatter interactively →