Protein de-ADP-ribosylation

Across TCGA patient cohorts, RNA activity of the Protein de-ADP-ribosylation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADPRH, HCLS1, and PKN1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein de-ADP-ribosylation activity versus ADPRH in GBM (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ADPRH →	+0.404	+0.099	<.001	<.001	3	8
UCEC	HCLS1 →	+0.489	+0.063	<.001	.003	3	6
COAD	PKN1 →	+0.181	+0.036	.003	.006	3	6
BRCA	STAT5A →	+0.309	+0.047	.001	.001	3	5
BRCA	WIPF1_S276 →	+0.305	+0.039	.002	.001	3	5
BRCA	DOCK10 →	+0.250	+0.040	.004	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051725 vs ADPRH — GBM

Explore this scatter interactively →