Biological process involved in intraspecies interaction between organisms

Across TCGA patient cohorts, RNA activity of the Biological process involved in intraspecies interaction between organisms pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CASP10, PTPN6, and ARHGAP25, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Biological process involved in intraspecies interaction between organisms activity versus CASP10 in BRCA (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CASP10 →	-0.434	-0.025	.002	<.001	3	6
HNSC	PTPN6 →	-0.268	-0.023	.002	.008	3	6
HNSC	ARHGAP25 →	-0.299	-0.025	.004	.004	3	5
GBM	HEATR1 →	-0.323	-0.078	<.001	<.001	3	5
PDAC	PRKAR2A →	+0.196	+0.035	<.001	<.001	3	5
UCEC	AHCTF1 →	-0.223	-0.042	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051703 vs CASP10 — BRCA

Explore this scatter interactively →