Biological process involved in intraspecies interaction between organisms

Across TCGA pan-cancer cohorts, RNA activity of the Biological process involved in intraspecies interaction between organisms pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 54 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Biological process involved in intraspecies interaction between organisms pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LGG and UVM, show the opposite pattern, with higher activity associated with better survival.

MESO, ACC, and LUAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	IV	0.154	0.498	.001	58	view →
ACC	DFS	Quartile	All	0.262	0.840	.002	45	view →
LUAD	DFS	Quartile	IV	0.372	0.789	.013	36	view →
LGG	OS	Median	All	0.936	0.857	<.001	34	view →
LIHC	DFS	Tertile	All	0.307	0.489	.004	29	view →
UVM	OS	Tertile	II,III,IV	0.780	0.396	.010	25	view →
HNSC	DFS	Median	II,III,IV	0.495	0.238	.004	22	view →
KIRP	OS	Median	All	0.975	0.892	.001	18	view →
UCS	DFS	Median	IV	0.367	0.952	.001	16	view →
COAD	OS	Tertile	All	0.737	0.843	.022	11	view →
PAAD	DFS	Quartile	All	0.539	0.227	.008	11	view →
ESCA	DFS	Quartile	III,IV	0.541	0.322	.021	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0051703–MESO (DFS)

Open the MESO breakdown →