Biological process involved in intraspecies interaction between organisms

Across TCGA patient cohorts, RNA activity of the Biological process involved in intraspecies interaction between organisms pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C5orf63, MLPH, and GARS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Biological process involved in intraspecies interaction between organisms activity versus C5orf63 in BRCA (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	C5orf63 →	+0.891	+0.319	<.001	.004	3	5
BRCA	MLPH →	+3.065	+0.508	<.001	<.001	3	5
BRCA	GARS1 →	-0.396	-0.317	.002	.002	3	5
LSCC	NPL →	-0.757	-0.284	<.001	.005	3	5
CCRCC	HRC →	+0.803	+0.291	<.001	<.001	3	5
CCRCC	TMEM88 →	+0.809	+0.349	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051703 vs C5orf63 — BRCA

Explore this scatter interactively →