Biological process involved in intraspecies interaction between organisms

Across TCGA cell cohorts, RNA activity of the Biological process involved in intraspecies interaction between organisms pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UGT2B11, ACACB, and SPHK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UGT2B11 grouped by Biological process involved in intraspecies interaction between organisms-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	UGT2B11 →	-0.166	-0.885	<.001	<.001	3	5
LUNG_NSCLC_LUAD	ACACB →	-0.131	-0.683	<.001	.001	3	4
URINARY_TRACT	SPHK2 →	-0.280	-1.989	.007	<.001	3	4
BLOOD_Myeloma	UVRAG →	-0.376	-1.428	.003	.002	3	4
PANCREAS	FNTB →	+0.173	+0.643	.001	.001	3	3
LUNG_NSCLC_LUAD	PGLYRP3 →	-0.121	-0.520	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UGT2B11 by Biological process involved in intraspecies interaction between organisms activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →