Biological process involved in intraspecies interaction between organisms

Across TCGA cell cohorts, RNA activity of the Biological process involved in intraspecies interaction between organisms pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGSM3, GINS4, and FBXO7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SGSM3 grouped by Biological process involved in intraspecies interaction between organisms-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SGSM3 →	+0.825	+0.968	.001	.001	3	4
BLOOD_Leukemia	GINS4 →	+1.126	+1.135	.005	<.001	3	4
LARGE_INTESTINE	FBXO7 →	+0.622	+1.067	<.001	<.001	3	4
LARGE_INTESTINE	HDDC2 →	+0.706	+1.154	.007	<.001	3	4
CNS	RAB10 →	+0.675	+1.169	<.001	<.001	3	4
URINARY_TRACT	CDHR3 →	-1.025	-1.272	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SGSM3 by Biological process involved in intraspecies interaction between organisms activity — LARGE_INTESTINE

Explore this box plot interactively →