Biological process involved in interaction with symbiont

Across TCGA cell cohorts, RNA activity of the Biological process involved in interaction with symbiont pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL35, HUWE1, and CYP2W1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLHL35 grouped by Biological process involved in interaction with symbiont-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KLHL35 →	-0.139	-0.195	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	HUWE1 →	-0.365	-0.167	.001	.002	3	5
BREAST	CYP2W1 →	-0.202	-0.228	.001	<.001	3	4
SOFT_TISSUE	TMEM254 →	-0.276	-0.223	.001	<.001	3	4
LUNG_NSCLC_LUSC	CHRNA4 →	-0.142	-0.231	<.001	.002	3	4
LUNG_NSCLC_LUSC	ARRB1 →	-0.126	-0.286	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLHL35 by Biological process involved in interaction with symbiont activity — PANCREAS

Explore this box plot interactively →