Protein delipidation

Across TCGA cell cohorts, RNA activity of the Protein delipidation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATG4D, ATG4C, and SIRT6, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATG4D grouped by Protein delipidation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ATG4D →	-0.310	-1.448	<.001	<.001	3	12
CNS	ATG4C →	-0.231	-0.968	<.001	<.001	3	9
LARGE_INTESTINE	SIRT6 →	-0.240	-1.060	.002	.003	3	7
CNS	ATG4B →	-0.208	-1.056	<.001	.001	3	7
BREAST	KCNC3 →	-0.171	-0.820	.005	.003	3	7
BLOOD_Leukemia	SLIT2 →	-0.309	-1.355	<.001	<.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATG4D by Protein delipidation activity — LUNG_SCLC

Explore this box plot interactively →