Pointed-end actin filament capping

Across TCGA patient cohorts, RNA activity of the Pointed-end actin filament capping pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TMOD2, TPM1, and PALM2AKAP2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pointed-end actin filament capping activity versus TMOD2 in LSCC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TMOD2 →	+0.492	+0.115	<.001	<.001	3	9
UCEC	TPM1 →	+0.667	+0.115	<.001	<.001	3	9
CCRCC	PALM2AKAP2 →	+0.481	+0.127	<.001	<.001	3	9
UCEC	RSU1 →	+0.508	+0.094	<.001	<.001	3	8
UCEC	SEPTIN2 →	+0.245	+0.079	<.001	<.001	3	8
UCEC	SORBS3 →	+0.590	+0.098	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051694 vs TMOD2 — LSCC

Explore this scatter interactively →