Nuclear pore localization

Across TCGA patient cohorts, RNA activity of the Nuclear pore localization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYDE1, ISLR, and MYL9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear pore localization activity versus SYDE1 in BRCA (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SYDE1 →	+0.521	+0.182	.008	.003	3	7
GBM	ISLR →	+1.128	+0.188	.001	<.001	3	7
UCEC	MYL9 →	+1.021	+0.156	<.001	<.001	3	6
UCEC	ASPN →	+1.079	+0.122	<.001	.004	3	6
UCEC	ACTA2 →	+1.243	+0.165	.007	.001	3	6
UCEC	GLT8D2 →	+0.702	+0.135	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051664 vs SYDE1 — BRCA

Explore this scatter interactively →