Nuclear pore localization

Across TCGA cell cohorts, RNA activity of the Nuclear pore localization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FXR1, ABCF3, and IL15RA, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear pore localization activity versus FXR1 in OESOPHAGUS (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FXR1 →	+0.998	+0.160	.006	<.001	2	7
BLOOD_Lymphoma	ABCF3 →	+0.657	+0.223	.008	.003	3	6
BLOOD_Lymphoma	IL15RA →	+3.411	+0.218	<.001	<.001	3	5
BLOOD_Lymphoma	STAT4 →	+1.578	+0.164	<.001	.002	3	5
OVARY	SENP2 →	+0.894	+0.104	.002	.005	2	6
LUNG_NSCLC_LUSC	EME1 →	+0.922	+0.235	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051664 vs FXR1 — OESOPHAGUS

Explore this scatter interactively →