Maintenance of centrosome location

Across TCGA patient cohorts, RNA activity of the Maintenance of centrosome location pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CENPF_S3079, CSE1L, and GMPS, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of centrosome location activity versus CENPF_S3079 in UCEC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPF_S3079 →	+1.167	+0.111	<.001	<.001	3	9
LSCC	CSE1L →	+0.318	+0.063	.001	.001	3	9
LSCC	GMPS →	+0.402	+0.081	<.001	<.001	3	9
LSCC	MSH6 →	+0.490	+0.077	<.001	<.001	3	9
BRCA	PAICS_S27 →	+1.139	+0.051	<.001	<.001	3	9
LUAD	RFC1 →	+0.343	+0.082	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051661 vs CENPF_S3079 — UCEC

Explore this scatter interactively →