Maintenance of centrosome location

Across TCGA patient cohorts, RNA activity of the Maintenance of centrosome location pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RN7SKP64, RAP2CP1, and PAQR4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of centrosome location activity versus RN7SKP64 in UCEC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP64 →	-0.728	-0.712	.002	.002	3	3
LUAD	RAP2CP1 →	-0.427	-0.278	<.001	<.001	3	3
BRCA	PAQR4 →	+0.527	+0.186	.002	<.001	3	3
BRCA	NUAK2 →	+0.534	+0.212	.005	.001	3	3
CCRCC	FTLP15 →	-1.203	-0.604	.001	.002	3	3
BRCA	CDC42P6 →	-0.664	-0.188	.008	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051661 vs RN7SKP64 — UCEC

Explore this scatter interactively →