Maintenance of centrosome location

Across TCGA cell cohorts, RNA activity of the Maintenance of centrosome location pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADCY7, PCSK1N, and BMF, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of centrosome location activity versus ADCY7 in LUNG_SCLC (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ADCY7 →	+4.010	+0.500	.009	.001	2	1
BONE	PCSK1N →	+4.655	+0.776	.001	.003	2	1
BONE	BMF →	+3.735	+0.761	.001	.005	2	1
BONE	GRIK5 →	+4.405	+0.761	<.001	.005	2	1
BONE	MORN1 →	+2.114	+0.761	.005	.005	2	1
BONE	CDK18 →	+3.380	+0.718	.004	<.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051661 vs ADCY7 — LUNG_SCLC

Explore this scatter interactively →