Establishment of centrosome localization

Across TCGA patient cohorts, RNA activity of the Establishment of centrosome localization pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC9A9, DLGAP4_T915, and ISYNA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of centrosome localization activity versus SLC9A9 in BRCA (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC9A9 →	-0.721	-0.044	.001	.001	2	6
LSCC	DLGAP4_T915 →	+0.571	+0.048	<.001	.001	3	5
LSCC	ISYNA1 →	+0.299	+0.041	.007	.004	3	5
LUAD	MTDH →	-0.207	-0.056	.007	.001	2	6
CCRCC	USO1 →	-0.170	-0.041	<.001	.001	3	5
GBM	RHBDF2 →	-0.484	-0.067	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051660 vs SLC9A9 — BRCA

Explore this scatter interactively →