Establishment of centrosome localization

Across TCGA cell cohorts, RNA activity of the Establishment of centrosome localization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHF5A, CDKL3, and MRPL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHF5A grouped by Establishment of centrosome localization-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PHF5A →	-0.767	-0.323	.003	.003	3	4
LIVER	CDKL3 →	+0.646	+0.273	<.001	<.001	3	3
SKIN	MRPL3 →	+0.553	+0.228	.001	.009	2	4
SKIN	CNBP →	+0.546	+0.268	<.001	.006	3	3
SKIN	SPDYE2 →	-0.629	-0.251	.001	<.001	3	3
SKIN	POLR2J2 →	-1.183	-0.333	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHF5A by Establishment of centrosome localization activity — OESOPHAGUS

Explore this box plot interactively →