Establishment of centrosome localization

Across TCGA cell cohorts, RNA activity of the Establishment of centrosome localization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F3, ANXA3, and GJB3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of centrosome localization activity versus F3 in OESOPHAGUS (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	F3 →	+2.633	+0.181	.001	.003	3	5
LUNG_NSCLC_LUAD	ANXA3 →	+2.037	+0.195	.001	<.001	3	5
OESOPHAGUS	GJB3 →	+2.975	+0.300	.002	.001	3	5
KIDNEY	NRG2 →	-1.404	-0.209	<.001	.007	3	5
SKIN	TJP1 →	+0.746	+0.208	.003	.005	2	5
PANCREAS	WASF1 →	-1.130	-0.347	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051660 vs F3 — OESOPHAGUS

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