Spindle localization

Across TCGA patient cohorts, RNA activity of the Spindle localization pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUT1, BMI1, and ZRSR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spindle localization activity versus TUT1 in OV (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TUT1 →	-0.442	-0.164	.007	.001	3	4
UCEC	BMI1 →	+0.695	+0.107	<.001	.006	3	4
BRCA	ZRSR2 →	-0.368	-0.149	.001	.001	3	4
BRCA	SAPCD1 →	-0.489	-0.172	.003	<.001	3	4
OV	WDR74 →	-0.308	-0.126	.006	.003	3	3
OV	LUM →	+1.221	+0.107	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051653 vs TUT1 — OV

Explore this scatter interactively →