Nucleus localization

Across TCGA patient cohorts, RNA activity of the Nucleus localization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PHLDB1_S404, CNRIP1, and RPS16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleus localization activity versus PHLDB1_S404 in LSCC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PHLDB1_S404 →	+0.447	+0.030	<.001	<.001	3	5
BRCA	CNRIP1 →	+0.450	+0.022	<.001	<.001	3	5
HNSC	RPS16 →	-0.176	-0.054	<.001	<.001	3	5
HNSC	FAM83H_S870 →	-0.805	-0.082	<.001	<.001	3	5
LSCC	PHLDB1_S430 →	+0.944	+0.035	<.001	<.001	3	5
LSCC	PPP2R5D_S90 →	+0.830	+0.044	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051647 vs PHLDB1_S404 — LSCC

Explore this scatter interactively →