Nucleus localization

Across TCGA patient cohorts, RNA activity of the Nucleus localization pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAD2L1, UBE2C, and CENPA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleus localization activity versus MAD2L1 in UCEC (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAD2L1 →	-0.840	-0.147	.001	<.001	3	5
UCEC	UBE2C →	-1.110	-0.115	.005	.003	3	5
UCEC	CENPA →	-1.137	-0.178	<.001	<.001	3	4
UCEC	HROB →	-0.622	-0.113	.004	.006	3	4
UCEC	CENPE →	-0.833	-0.156	.002	<.001	3	4
UCEC	MTFR2 →	-0.973	-0.181	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051647 vs MAD2L1 — UCEC

Explore this scatter interactively →