Nucleus localization

Across TCGA cell cohorts, RNA activity of the Nucleus localization pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC102B, POLR2D, and CYB5R3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleus localization activity versus CCDC102B in SOFT_TISSUE (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCDC102B →	+1.506	+0.091	<.001	.004	3	5
OESOPHAGUS	POLR2D →	-0.654	-0.201	<.001	.003	3	5
BREAST	CYB5R3 →	+0.851	+0.158	.005	<.001	3	5
BREAST	FAM89B →	+0.571	+0.128	.004	<.001	3	5
LIVER	RPL23A →	-0.936	-0.159	.003	.009	2	5
SOFT_TISSUE	NOL3 →	+1.521	+0.121	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051647 vs CCDC102B — SOFT_TISSUE

Explore this scatter interactively →