Mitochondrion localization

Across TCGA patient cohorts, RNA activity of the Mitochondrion localization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B_S1208, MAP1B_S1965, and PHF6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrion localization activity versus MAP1B_S1208 in LSCC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B_S1208 →	+1.187	+0.049	<.001	<.001	3	7
LSCC	MAP1B_S1965 →	+0.906	+0.048	<.001	<.001	3	7
LUAD	PHF6 →	+0.255	+0.038	.002	<.001	3	6
LSCC	CACYBP →	+0.333	+0.048	.002	<.001	3	6
BRCA	DUSP12 →	+0.313	+0.024	<.001	.003	3	6
LSCC	MAP1B_S1298 →	+0.769	+0.039	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051646 vs MAP1B_S1208 — LSCC

Explore this scatter interactively →