Mitochondrion localization

Across TCGA patient cohorts, RNA activity of the Mitochondrion localization pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP1B, KIF7, and KLHDC8A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrion localization activity versus MAP1B in LSCC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B →	+1.949	+0.608	<.001	<.001	3	7
CCRCC	KIF7 →	+0.466	+0.294	.001	<.001	3	6
LUAD	KLHDC8A →	+0.685	+0.490	<.001	<.001	2	7
LSCC	ADAMTSL1 →	+0.791	+0.424	<.001	<.001	3	5
LUAD	RTL8B →	+0.463	+0.346	.001	.002	3	5
LSCC	DST-AS1 →	+0.563	+0.425	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051646 vs MAP1B — LSCC

Explore this scatter interactively →