Mitochondrion localization

Across TCGA cell cohorts, RNA activity of the Mitochondrion localization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXOSC9, PGBD1, and GPX1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrion localization activity versus EXOSC9 in OESOPHAGUS (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	EXOSC9 →	-0.698	-0.244	.009	.004	3	4
OESOPHAGUS	PGBD1 →	-0.779	-0.219	.002	.002	3	4
URINARY_TRACT	GPX1 →	-1.275	-0.230	.001	.007	3	3
BLOOD_Lymphoma	AGTPBP1 →	+0.903	+0.515	.001	.007	3	3
BLOOD_Lymphoma	SESTD1 →	+1.322	+0.578	.006	.005	3	3
BONE	ARHGEF3 →	+1.992	+0.190	.008	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051646 vs EXOSC9 — OESOPHAGUS

Explore this scatter interactively →