Golgi localization

Across TCGA patient cohorts, RNA activity of the Golgi localization pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM92-AS1, PRKCD, and PPP2R3B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi localization activity versus TMEM92-AS1 in COAD (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TMEM92-AS1 →	+0.587	+0.116	<.001	<.001	3	3
BRCA	PRKCD →	-0.698	-0.151	<.001	<.001	3	3
PDAC	PPP2R3B →	-0.210	-0.572	.004	.007	3	3
LUAD	LINC02207 →	-0.271	-0.558	<.001	.005	3	3
OV	NDNF →	+0.609	+0.108	<.001	.002	3	3
LUAD	IFT43 →	-0.308	-0.468	.004	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051645 vs TMEM92-AS1 — COAD

Explore this scatter interactively →