Response to electrical stimulus

Across TCGA cell cohorts, RNA activity of the Response to electrical stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHD7, LMBR1L, and RASA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHD7 grouped by Response to electrical stimulus-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CHD7 →	+0.982	+0.932	.008	<.001	3	4
OESOPHAGUS	LMBR1L →	+1.033	+1.132	.002	<.001	3	4
OESOPHAGUS	RASA1 →	+0.768	+1.445	.009	<.001	3	4
OESOPHAGUS	CNOT11 →	+0.684	+1.122	.001	.005	3	4
SKIN	SLC25A14 →	-0.643	-1.241	.006	<.001	3	4
LIVER	GPR143 →	+2.021	+1.510	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHD7 by Response to electrical stimulus activity — BREAST

Explore this box plot interactively →