Exocyst localization

Across TCGA patient cohorts, RNA activity of the Exocyst localization pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBX3P9, HMGB1P5, and CHCHD2P9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Exocyst localization activity versus CBX3P9 in COAD (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CBX3P9 →	-0.467	-0.120	.005	<.001	3	5
UCEC	HMGB1P5 →	-0.611	-0.175	.001	.008	3	4
COAD	CHCHD2P9 →	-0.805	-0.111	.001	.006	3	4
BRCA	EIF4HP1 →	-0.589	-0.114	.004	.006	3	4
GBM	DBF4 →	-0.580	-0.156	.002	.001	3	4
BRCA	THOC5 →	-0.436	-0.169	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051601 vs CBX3P9 — COAD

Explore this scatter interactively →