Response to folic acid

Across TCGA patient cohorts, RNA activity of the Response to folic acid pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAPLN3, GMFG, and LINC01554, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to folic acid activity versus HAPLN3 in BRCA (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HAPLN3 →	+1.087	+0.353	.005	.002	3	5
BRCA	GMFG →	+0.447	+0.402	.004	.001	3	4
HNSC	LINC01554 →	+0.532	+0.170	.001	<.001	3	4
UCEC	LOX →	+1.222	+0.344	<.001	<.001	3	4
LUAD	THEMIS2 →	+0.531	+0.124	.001	.001	3	4
LUAD	DOK2 →	+0.540	+0.110	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051593 vs HAPLN3 — BRCA

Explore this scatter interactively →