Response to folic acid

Across TCGA pan-cancer cohorts, RNA activity of the Response to folic acid pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 10 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Response to folic acid pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and HNSC, show the opposite pattern, with higher activity associated with better survival.

UVM, HNSC, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.725	0.326	<.001	105	view →
HNSC	OS	Tertile	All	0.448	0.276	<.001	96	view →
KIRC	DFS	Tertile	II,III,IV	0.429	0.773	<.001	47	view →
LGG	OS	Median	All	0.367	0.522	<.001	47	view →
ESCA	DFS	Median	II,III,IV	0.420	0.211	.004	36	view →
OV	DFS	Tertile	III,IV	0.112	0.190	.009	28	view →
LUAD	DFS	Quartile	All	0.482	0.289	.003	27	view →
KICH	OS	Median	III,IV	0.785	1.000	.015	18	view →
KIRP	OS	Median	All	0.969	0.895	.011	14	view →
THCA	OS	Median	All	0.978	0.902	.012	13	view →
PRAD	DFS	Quartile	All	0.890	0.958	.013	12	view →
GBM	DFS	Median	All	0.179	0.381	.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0051593–UVM (DFS)

Open the UVM breakdown →