Response to folic acid

Across TCGA cell cohorts, RNA activity of the Response to folic acid pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TYMS, GPX1, and OGG1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TYMS grouped by Response to folic acid-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TYMS →	-0.628	-1.279	<.001	<.001	3	14
BLOOD_Leukemia	GPX1 →	-0.272	-1.372	.001	<.001	3	6
KIDNEY	OGG1 →	-0.355	-1.460	.006	.001	3	5
SKIN	WIPI2 →	-0.197	-1.038	.002	<.001	3	5
BREAST	B3GNT6 →	-0.260	-1.246	.001	<.001	3	5
PANCREAS	RRM1 →	-0.513	-1.070	.003	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TYMS by Response to folic acid activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →